PD-L1 蛋白, Mouse (Biotinylated, HEK293, His)

产品包装规格：

种属：              Human Cells

表达系统：      Prokaryotic expression system、Eukaryotic expression system 

标签：             not have

同用名：          CD274; PDL1; PD-L1; PD-L1B7 homolog 1; B7-H; B7H1; B7-H1; PDCD1L1; PDCD1LG1

分子量：          51.9 KDa

纯度：             Greater than 95% as determined by Tris-Bis PAGE.

储存条件：      Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.

备注：             Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
                       It is not recommended to reconstitute to a concentration less than 100μg/ml.
                       Dissolve the lyophilized protein in distilled water.
                       Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

储存时间：      Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
                       Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
                       Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

运输：             The product is shipped at ambient temperature.

                       Upon receipt, store it immediately at the temperature listed below.

背景：            Human Programmed cell death 1 ligand 1(Cd274,PD-L1), is a member of the growing B7 family of immune proteins.It involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.B7-H1 has been identified as one of two ligands for programmed death1    (PD1), a member of the CD28 family of immunoreceptors. B7-H1 is constitutively expressed in several organs such as heart, skeletal muscle B7-H1 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. The costimulatory function of B7-H1 is critical for enhancing maturation and differentiation of T-cells in lymphoid organs.B7-H1 expression is alsoinduced in dendritic cells and keratinocytes after IFN gamma stimulation. Interaction of B7-H1 with PD1 results in inhibition of TCR-mediated proliferation and cytokine production. The B7-H1:PD1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral   tolerance.

样品信息：

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