溶菌酶（lysozyme）人源
产品包装规格：
价格 | 大包装询价 | 量大优惠 |
1 mg | ￥1000 | In-stock |
10 mg | ￥5000 | In-stock |
50 mg | ￥15000 | 询价 |
100 mg | ￥------- | 询价 |
种属： Human Cells
表达系统： Prokaryotic expression system、Eukaryotic expression system
标签： N-His
同用名： Lysozyme、 muramidase、N-acetylmuramide glycanohydrlase
分子量： 14.7 kD
纯度： Greater than 95% as determined by Tris-Bis PAGE.
储存条件： Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 100mM NaCl, pH7.5.
备注： Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存时间： Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输： The product is shipped at ambient temperature.
Upon receipt, store it immediately at the temperature listed below.
背景： 重组人溶菌酶是经生物技术改构后产生的一类对 G+ 和 G- 菌都有抗菌效应的一类新药。
人溶菌酶 (hLYZ) 又称胞壁质酶, 能水解细菌细胞壁中粘多糖的β1~4糖苷键, 对革兰氏阳性细菌具有直接的溶解作用, 在分泌型免疫球蛋白A和补体的参与下, 对革兰氏阴性细菌具有间接的溶解作用。用于临床治疗, hLYZ具有消炎、消肿、组织修复、改善组织局部血液循环和分解脓液等药理作用。hLYZ还能与带负电荷的病毒蛋白直接作用, 并能与DNA、RNA和脱辅基蛋白形成复盐而使病毒失活。
人溶菌酶是一种人体内天然存在的具有抗菌、抗病毒、抗炎、增强免疫力等特性的蛋白质。它直接作用于细菌细胞壁, 因此, 细菌对其完全不存在耐药性, 也无免疫原性。利用基因工程生产出的重组人溶菌酶不仅具有人溶菌酶的优点, 同时也克服了人溶菌酶活性低、产量低、不便于制备、无法稳定保存等缺点。在抗菌药物滥用、耐药菌株广泛存在的今天, 由于其特性可以弥补众多抗生素的不足, 具有广泛的临床应用前景。
Recombinant human lysozyme is a kind of new drug which has antibacterial effect on both G+ and G- bacteria after modification by biotechnology.
Human lysozyme (hLYZ), also known as cytoplasmic enzyme, can hydrolyze the β1~4 glycosidic bonds of mucosaccharides in bacterial cell walls, and has direct dissolution effect on Gram-positive bacteria, and indirect dissolution effect on Gram-negative bacteria with the participation of secreted immunoglobulin A and complement. For clinical treatment, hLYZ has pharmacological effects such as reducing inflammation, detumescence, tissue repair, improving local blood circulation and decomposingpus. hLYZ can also interact directly with negatively charged viral proteins, and can form double salts with DNA, RNA and apoprotein to inactivate the virus.
Human lysozyme is a kind of protein that exists naturally in human body with antibacterial, antiviral, anti-inflammatory and immune-enhancing properties. It acts directly on the bacterial cell wall, so there is no resistance to it and no immunogenicity. The recombinant human lysozyme produced by genetic engineering not only has the advantages of human lysozyme, but also overcomes the disadvantages of low activity, low yield, difficult preparation and unstable preservation of human lysozyme. Nowadays, antimicrobial abuse and drug-resistant strains are widespread. Because of its characteristics, it can make up for the deficiency of many antibiotics, and has a wide clinical application prospect.
样品信息：
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我们公司专注于抗菌肽的研发和商业化应用，致力于解决全球性的第五大健康威胁 ——耐药菌感染。通过制备和验证抗菌肽的活性，我们能够为公共卫生事业做出积极贡 献。此外，我们还提供蛋白质结构解析的 CRO 客户服务，帮助科学家们解析蛋白质的 结构，以便更好地理解生物分子的工作原理。为了进一步提高我们的技术水平，我们正 在建设生物酶催化技术平台，并努力丰富酶库资源以更好地满足客户的需求。我们相信， 酶催化技术平台将有助于加速新药研发进程，并为药物筛选和开发提供支持。同时，我 们也正在建立高效的酶催化工艺，以满足客户对酶制剂加工和生产的要求以及技术咨询 服务。除了上述领域，我们还关注稳定同位素标记试剂的生产研发。稳定同位素在生物 学、医学等领域具有重要的应用价值，我们希望能够填补国内在这方面的技术空白并为 其提供高质量的服务。
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