人纤维连接蛋白、Fibronectin human、FN、人源

产品包装规格：

种属：              Human Cells

表达系统：      Prokaryotic expression system、Eukaryotic expression system 

标签：              N-His-C

同用名：          人纤维连接蛋白、Fibronectin human、FN、Cold-insoluble globulin、fibronectin、CIG、纤连蛋白

分子量：          150 KDa

纯度：             Greater than 95% as determined by Tris-Bis PAGE.

储存条件：       Lyophilized from a 0.2 μm filtered solution of  20mM Tris, 100mM NaCl, pH7.5
                        Freeze dried by cover buffered brine

备注：              Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
                        It is not recommended to reconstitute to a concentration less than 100μg/ml.
                        Dissolve the lyophilized protein in distilled water.
                        Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

储存时间：      Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
                       Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
                       Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

运输：             The product is shipped at ambient temperature.

                  Upon receipt, store it immediately at the temperature listed below.

背景：            细胞纤连蛋白（fibronectin，FN）是一种细胞外糖蛋白，分别以可溶形式存在于体液中，或以不可溶形式存在于细胞外 基质中。作为主要的细胞粘附分子之一，FN 在许多重要的生理过程中起着关键性作用，如胚胎生成，伤口愈合，止血和血 栓形成。纤连蛋白表达的改变，降解以及组合与大量的病理发生密切相关，包括癌症和纤维化。

纤连蛋白（FN）的应用：1）作为细胞培养基质；功能在于促进细胞生长，提高细胞贴壁率，增强细胞代谢水平，缩短细胞生长时间；杂交瘤技术中提高细胞融合率等。2）疾病诊断和治疗；功能在于伤口修复和愈合，癌症诊断和治疗，治疗血管系统和心脑血管疾病等。

本产品是来源于原核或真核表达体系所得到的重组人纤连蛋白，以单体形式存在，可作为一种细胞培养基质，替换Matrigel、鼠尾胶原、血源纤连蛋白等，提高细胞贴壁率，增强细胞代谢水平，缩短细胞生长周期。也可直接添加到培养基中，替换或降低血清使用量，促进细胞贴壁、迁移、移动生长、维持细胞状态。

在不断的研究和临床应用中，我们发现纤连蛋白FN不仅对慢性创面、各类伤口、损伤皮肤有很好的修复效果，而且对于健康肌肤也有很好的抗衰、脱敏、舒缓、紧致、保湿等功效，而且我们最近的透皮实验、划痕实验、保湿等功效实验都已经完成，充分证明纤连蛋白FN在化妆品领域可以大有作为。

fibronectin (FN) is an extracellular glycoprotein that exists in either a soluble form in body fluids or an insoluble form in the extracellular matrix. As one of the major cell adhesion molecules, FN plays a key role in many important physiological processes, such as embryo formation, wound healing, hemostasis, and thrombolysis. Changes in fibronectin expression, degradation, and combination are closely associated with a large number of pathologies, including cancer and fibrosis.

Applications of fibronectin (FN) : 1) as a cell culture substrate; The function is to promote cell growth, improve cell adhesion rate, enhance cell metabolism level, shorten cell growth time; Hybridoma technology to improve the rate of cell fusion. 2) Diagnosis and treatment of diseases; Functions lie in wound repair and healing, cancer diagnosis and treatment, treatment of vascular system and cardiovascular and cerebrovascular diseases.

This product is a recombinant human fibronectin derived from prokaryotic or eukaryotic expression system. Existing in monomer form, it can be used as a cell culture substrate to replace Matrigel, rat tail collagen, blood-derived fibronectin, etc., improve cell adhesion rate, enhance cell metabolism level, and shorten cell growth cycle. It can also be directly added to the medium to replace or reduce the amount of serum, promote cell adhesion, migration, mobile growth, and maintain cell state.

In the continuous research and clinical application, we have found that fibrontenin FN not only has a good repair effect on chronic wounds, various wounds and damaged skin, but also has a good effect on healthy skin, such as anti-aging, desensitization, soothing, firming and moisturizing. Moreover, our recent transdermal experiment, scratch experiment and moisturizing experiment have been completed. It is fully proved that fibronectin FN has great potential in the field of cosmetics.

样品信息：

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